Space shuttle Atlantis and its seven-astronaut crew undocked from the International Space Station at 4:43 a.m. EST (09:43 UTC) on November 25, 2009.
Atlantis is scheduled to land at Kennedy Space Center, Fla., Friday.
The 11-day Atlantis mission will return ISS crew member Nicole Stott to Earth and is expected to be the final space shuttle crew rotation flight. Stott spent two and a half months on board the ISS.
When the mission completed, only five U.S. space shuttle flights will remain before the shuttle fleet is retired next year. Russian, European and Japanese space freighters will keep the ISS supplied until NASA deploys its new capsule-style Orion spacecraft.