On October 17, 2021 at 04:35 UTC the Russian “Soyuz MS-18” landing capsule landed safely in Kazakhstan, 156 km at the southeast of the town of Dzhezkazgan. The spacecraft delivered to Earth one member of Expedition 65 – Russian cosmonauts Oleg Novickiy as well as 2 spaceflight-participants: film director Klim Shipenko and spaceflight-participant, actress Yulia Peresild. All three are from Russia. Oleg Novickiy spent in space 190 days, 20 hours and 53 minutes. Klim Shipenko and Yulia Peresild spent in space 11 days, 19 hours and 40 minutes.

Seven other ISS crew members - Robert Kimbrough, Katherine Megan McArthur, Akihiko Hoshide, Thomas Pesquet, Anton Shkaplerov, Pyotr Dubrov and Mark Vande Hei remained in orbit aboard the International Space Station as the Expedition 66 crew. The undocking of Soyuz MS-18 marked the end of Expedition 65 and the start of Expedition 66.