The Space Mail Cover regarded to Expedition 52 mission aboard the International Space Station as well as Italian Astronaut Paolo Nespoli's mission called VITA. Vita is an acronym for Vitality, Innovation, Technology and Ability. In addition, in Italian it means life, reflecting the scientific experiments and the technologies needed for life in space.

The cover was marked with all proper board seals, including the “Russian Post. Board of ISS. Russian Segment” round board post mark dated July 29, 2017, the day when the Russian Soyuz MS-05 spacecraft docked with the International Space Station. The cover was autographed by all crewmates who were aboard the ISS at the day of docking: Russian cosmonauts Sergey Ryazansky and Fyodor Yurchikhin; Italian astronaut Paolo Nespoli; American astronauts Randolph Bresnik, Peggy Whitson and Jack Fisher.