On February 22, 2021, the American "Cygnus” CRS-15 (NG-15, the S. S. Katherine Johnson) private unmanned supply spacecraft was docked to the International Space Station (ISS). The Cygnus spacecraft was grappled by a robotic arm at 09:38 UTC. The cargo spacecraft was docked to the station’s "Unity” module at 12:16 UTC. The spacecraft delivered about 3700 kilograms of supplies to the Space Station. It was the 15^th docking of a "Cygnus” spacecraft with the ISS. This is the 4^th flight of Cygnus under the CRS-2 contract.

On February 20, 2021 at 17:36 UTC the "Cygnus” privately owned U.S. unmanned supply spacecraft was launched from the Mid-Atlantic Regional Spaceport (MARS), a commercial space launch facility located at the southern tip of NASA's Wallops Flight Facility on Wallops Island, Virginia, USA. The spacecraft was orbited by the “Antares-230” rocket-carrier. The "Cygnus” NG-15 (the S. S. Katherine Johnson), previously known as CRS OA-15, unmanned supply spacecraft, built by U.S. space firm Orbital Sciences Corp., was orbited on its cargo resupply mission to the International Space Station. CRS means Commercial Resupply Services. The "Cygnus” NG-15 is the 15^th successful flight of the Orbital ATK uncrewed resupply spacecraft Cygnus.

On February 17, 2021 at 06:26 UTC the Russian “Progress MS-16” unmanned supply spacecraft docked to the International Space Station. The spacecraft was docked by using manual docking system operated by Expedition 64 commander, Russian cosmonaut Sergey Ryzhikov to the “Pirs” module of the ISS. The spacecraft delivered about 2500 kilograms of cargo for the ISS crew.

American female astronaut Millie Elizabeth Hughes-Fulford passed away on February 2, 2021. She performed 1 space flights by Space Shuttle Columbia (STS-40) in June 1991.

On February 1, 2021 American astronauts Michael Hopkins and Victor Glover performed the spacewalk to complete solar array battery replacement work that began four years ago. They also installed three new video cameras and made preparations for upcoming work to install new roll-out solar blankets to upgrade the lab’s power system. The EVA lasted 5 hours and 20 minutes. It was the 4^th spacewalk for Michael Hopkins and the 2^nd spacewalk for Victor Glover.

On January 27, 2021 American astronauts Michael Hopkins and Victor Glover performed the spacewalk to install a European Space Agency data relay antenna and to connect four of six cables to partially power a new ESA experiment platform. They also removed two solar array handling fixtures to clear the way for a future power system upgrade. The EVA lasted 6 hours and 56 minutes. It was the 3rd spacewalk for Michael Hopkins and the 1^st spacewalk for Victor Glover.

On January 14, 2021 at 01:26 UTC the "Dragon” capsule splashed down in the Gulf of Mexico off the coast of the US state of Florida. It was the "SpaceX CRS-21” mission. CRS means Commercial Resupply Services. It was the first flight of the new generation of Dragon cargo capsules also known SpaceX Dragon 2 or Cargo Dragon 2. It was the 21st flight of Cargo Dragon to the ISS with docking, including a demonstration flight in 2012.

On January 12, 2021 at 14:05 UTC, the Dragon CRS-21 spacecraft was undocked from the International Space Station. It’s the first flight of the new generation of Dragon cargo capsules also known SpaceX Dragon 2 or Cargo Dragon 2. It was the 21^st flight of Cargo Dragon to the ISS with docking, including a demonstration flight in 2012.

On January 11, 2021 American astronaut William Edgar Thornton passed away. He was 91. He performed 2 space flights by American Space Shuttle – STS-8 and STS-51B missions.

On January 6, 2021, the US "Cygnus” CRS-14 (NG-14 “Kalpana Chawla”) unmanned supply spacecraft was undocked from the International Space Station. After that, the spacecraft, was released by using the “Canadarm-2” orbiting complex's huge robotic arm at 15:11 UTC. It was the 14^th successful flight of "Cygnus” to the ISS.