On December 5, 2019 at 17:29 UTC the "Falcon 9” rocket-carrier was launched from SLC-40 of the Cape Canaveral Air Force Station, Florida, USA. The launch was performed by the "SpaceX” private company supported by the 45th Space Wing of US Air Force. US private company SpaceX launched its "Dragon” (CRS-19 flight also known as SpX-19) unmanned spacecraft on a cargo resupply mission to the International Space Station. CRS means Commercial Resupply Services. It is the 20^th successful flight of a “Dragon” spacecraft and the 19^th successful flight of a “Dragon” to the ISS.

On December 2, 2019, American astronaut Andrew Morgan and Italian astronaut Luca Parmitano performed the 3^rd spacewalk to continue the repairing of the AMS-02 cosmic ray detector. The EVA (extravehicular activity) lasted 5 hours and 56 minutes. This was the 5^th spacewalk for Luca Parmitano and the 6^th for Andrew Morgan.

On November 29, 2019 the “Progress MS-12” unmanned supply spacecraft was deorbited. Non-burnt fragments of the spacecraft drowned in the remote area of the Pacific at 17:19 UTC.

On November 29, 2019 at 10:25 UTC the Russian “Progress MS-12” unmanned supply spacecraft was undocked from the International Space Station.

On November 15, 2019, American astronaut Andrew Morgan and Italian astronaut Luca Parmitano performed a spacewalk. It was the first of four spacewalks to repair the Alpha Magnetic Spectrometer, also designated AMS-02AMS-02 (a cosmic ray detector), breezing through work to prep the device for invasive surgery to splice in new coolant pumps and extend the instrument’s life probing the composition of the universe. The EVA (extravehicular activity) lasted 6 hours and 39 minutes. This was the third spacewalk for Luca Parmitano and the fourth for Andrew Morgan.

On November 4, 2019, the American "Cygnus” CRS-12 (NG-12 “S.S. Alan Bean”) private unmanned supply spacecraft was docked to the International Space Station (ISS). The Cygnus spacecraft was grappled by a robotic arm operated by American astronaut Jessica Meir inside the space station at 09:10 UTC. The cargo spacecraft was docked to the station’s "Unity” module at 11:21 UTC. The spacecraft delivered about 3705 kilograms of supplies to the Space Station. It was the 12^th docking of a "Cygnus” spacecraft with the ISS.

On November 3, 2019, the Japanese HTV "Kounotori-8” unmanned supply spacecraft was deorbited. The spacecraft reentered Earth's atmosphere at 02:09 UTC. Non-burnt fragments of the spacecraft sank in the Pacific.

On November 2, 2019 at 13:59 UTC the "Cygnus” privately owned U.S. unmanned supply spacecraft was launched from the Mid-Atlantic Regional Spaceport (MARS), a commercial space launch facility located at the southern tip of NASA's Wallops Flight Facility on Wallops Island, Virginia, USA. The spacecraft was orbited by the “Antares-230” rocket-carrier. The "Cygnus” NG-12 (previously known as CRS OA-12) unmanned supply spacecraft, built by U.S. space firm Orbital Sciences Corp., was orbited on its cargo resupply mission to the International Space Station. CRS means Commercial Resupply Services. The "Cygnus” NG-12 is the 12^th successful flight of the Orbital ATK uncrewed resupply spacecraft Cygnus.

On November 1, 2019, the Japanese "HTV Kounotori-8” unmanned supply spacecraft departed the International Space Station. First HTV-8 was disengaged with the space station's robotic arm from a docking port on the Harmony module. At 17:20 UTC the spacecraft was released by American astronauts Christina Koch and Jessica Meir.

On October 18, 2019 American astronauts Christina Koch and Jessica Meir performed the first all-female spacewalk to install a replacement battery charger in the Station’s solar power system. The EVA lasted 7 hours and 13 minutes. It was the 4th spacewalk for Christina Koch and the first one for Jessica Meir.